Cameron,
Certainly if you have a modified blog engine that accurately tracks changes like a wiki, it may work just as well. EXP098 was a good example - there are currently 43 previous versions by several researchers. Also, that experiment still has comments to be addressed - the stuff in bold and italics - so it is not "complete".

The blog we use to keep track of milestones (linking back to experiment pages on the wiki) is very important. I don't expect people to keep up on the project by "reading" the wiki lab notebook. That's hard to do even for people collaborating on the project. But, the raw data is available at any time by anyone for drilling down and resolving new hypotheses or making new observations.

So if you have something that acts like this blog-wiki hybrid system it probably will work just as well. I'd be happy to see if some of our data can fit - if anything it will bring some redundancy to our work, which is a good thing in the Science 2.0 world.

I think the main other issue is the third party time stamp. That's one reason I like using a service, like Wikispaces, hosted by a large stable company. It also makes it easier for people to replicate overnight at zero cost if they are interested in trying it.

But I think there is also a lot more to learn about the differences between how scientific fields (and researchers) operate. We may gain a better appreciation of this if a few of us do Open Notebook Science.